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1

The protein structure determines the sensitizing capacity of Brazil nut 2S albumin (Ber e1) in a rat food allergy model

Van Bilsen, Jolanda HM, Knippels, Léon MJ, Penninks, André H, Nieuwenhuizen, Willem F, De Jongh, Harmen HJ, Koppelman, Stef J

Journal:

Clinical and Translational Allergy

Year:

2013

Language:

english

File:

PDF, 194 KB

english, 2013

2

Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats

Jonathan D. de Jonge, Janine Ezendam, Léon M.J. Knippels, Jennie Odink, Milanthy S. Pourier, André H. Penninks, Raymond Pieters, Henk van Loveren

Journal:

Year:

2007

Language:

english

File:

PDF, 721 KB

english, 2007

3

Lactobacillus casei Shirota does not decrease the food allergic response to peanut extract in Brown Norway rats

Jonathan D. de Jonge, Janine Ezendam, Léon M.J. Knippels, André H. Penninks, Raymond Pieters, Henk van Loveren

Journal:

Year:

2008

Language:

english

File:

PDF, 421 KB

english, 2008

4

Oral animal models in food allergy research

Léon M.J. Knippels, AndréH. Penninks, Geert F. Houben

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 188 KB

english, 1997

5

Acute allergic skin response as a new tool to evaluate the allergenicity of whey hydrolysates in a mouse model of orally induced cow’s milk allergy

Betty C. A. M. Van Esch, Bastiaan Schouten, Gerard A. Hofman, Ton Van Baalen, Frans P. Nijkamp, Léon M. J. Knippels, Linette E. M. Willemsen, Johan Garssen

Journal:

Pediatric Allergy and Immunology

Year:

2010

Language:

english

File:

PDF, 316 KB

english, 2010

6

Non-digestible oligosaccharides reduce immunoglobulin free light-chain concentrations in infants at risk for allergy

Bastiaan Schouten, Betty C. A. M. Van Esch, Tom G. Kormelink, Guido E. Moro, Sertac Arslanoglu, Günther Boehm, Léon M. J. Knippels, Frank A. Redegeld, Linette E. M. Willemsen, Johan Garssen

Journal:

Pediatric Allergy and Immunology

Year:

2011

Language:

english

File:

PDF, 292 KB

english, 2011

7

Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3+ regulatory T-cells in the mesenteric lymph nodes

Betty C. A. M. van Esch, Bastiaan Schouten, Sander de Kivit, Gerard A. Hofman, Léon M. J. Knippels, Linette E. M. Willemsen, Johan Garssen

Journal:

Pediatric Allergy and Immunology

Year:

2011

Language:

english

File:

PDF, 307 KB

english, 2011

8

Assessment of Protein Allergenicity : Studies in Brown Norway Rats

LÉON M.J. KNIPPELS, ANDRÉ H. PENNINKS

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 243 KB

english, 2002

9

Immune-Mediated Effects upon Oral Challenge of Ovalbumin-Sensitized Brown Norway Rats: Further Characterization of a Rat Food Allergy Model

Léon M.J. Knippels, André H. Penninks, Joost J. Smit, Geert F. Houben

Journal:

Toxicology and Applied Pharmacology

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

10

Mechanisms of allergy and asthma

Alma J. Nauta, Ferdi Engels, Leon M. Knippels, Johan Garssen, Frans P. Nijkamp, Frank A. Redegeld

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 225 KB

english, 2008

11

Food-derived oligosaccharides exhibit pharmaceutical properties

Anneke Rijnierse, Prescilla V. Jeurink, Betty C.A.M. van Esch, Johan Garssen, Léon M.J. Knippels

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 174 KB

english, 2011

12

Recent advances using rodent models for predicting human allergenicity

Léon M.J. Knippels, André H. Penninks

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

13

Initiating mechanisms of food allergy: Oral tolerance versus allergic sensitization

Femke van Wijk, Léon Knippels

Journal:

Biomedicine & Pharmacotherapy

Year:

2007

Language:

english

File:

PDF, 249 KB

english, 2007

14

In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas

Betty C.A.M. van Esch, Karen Knipping, Prescilla Jeurink, Sicco van der Heide, Anthony E.J. Dubois, Linette E.M. Willemsen, Johan Garssen, Léon M.J. Knippels

Journal:

Toxicology Letters

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

15

The importance of dietary control in the development of a peanut allergy model in Brown Norway rats

Jonathan D. de Jonge, Léon M.J. Knippels, Janine Ezendam, Jennie Odink, André H. Penninks, Henk van Loveren

Journal:

Year:

2007

Language:

english

File:

PDF, 460 KB

english, 2007

16

Repeated dose oral toxicological evaluation of concentrated barley β-glucan in CD-1 mice including a recovery phase

Bryan Delaney, Ting Carlson, Guo-Hua Zheng, Richard Hess, Nathan Knutson, Scott Frazer, Karen Ostergren, Maaike van Zijverden, Leon Knippels, Diana Jonker, André Penninks

Journal:

Food and Chemical Toxicology

Year:

2003

Language:

english

File:

PDF, 569 KB

english, 2003

17

Evaluation of three human Fc(RI transfected RBL cell lines for identifying functional IgE-allergen interactions using peanut allergic patient sera

Jolanda van Bilsen, Leon Knippels, Mary-lene Brouwer, Lothar Vogel, Gregory Ladics

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 82 KB

english, 2007

18

The sensitizing potential of different food proteins in an oral Brown Norway (BN) rat food allergy model

Goodman, Richard E, Penninks, AH, Astwood, James, Rice, Elena, Holleschak, Gyula, Thoma, Richard, Knippels, Leon

Journal:

Journal of Allergy and Clinical Immunology

Year:

2002

Language:

english

File:

PDF, 125 KB

english, 2002

19

Continued expression of anti-soy protein antibodies in rats bred on a soy protein–free diet for one generation: The importance of dietary control in oral sensitization research☆☆☆★★★

Knippels, Léon M., Penninks, André H., Houben, Geert F.

Journal:

Journal of Allergy and Clinical Immunology

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

20

Determination of protein allergenicity: studies in rats

André H. Penninks, Leon M.J. Knippels

Journal:

Toxicology Letters

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

21

Sa2071 Galectin-9 Induced by Dietary Synbiotics is Involved in Suppression of Allergic Symptoms in Mice and Humans

de Kivit, Sander, Saeland, Eirikur, Kraneveld, Aletta D., van de Kant, Henk, Schouten, Bastiaan, van Esch, Betty C., Knol, Jan, Sprikkelman, Aline B., van der Aa, Leontien B., Knippels, Léon, van Kooy

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

22

Sa2056 Supplementation of Ovalbumin-Sensitized Mice With Specific Non-Digestible Oligosaccharides During Pregnancy or Lactation Leads to Desensitization in the Offspring

Hogenkamp, Astrid, van Esch, Betty C., Knippels, Léon, Garssen, Johan

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 156 KB

english, 2012

23

Mo1695 Specific Non-Digestible Oligosaccharides Combined With B. Breve M-16V Attenuates Experimental Colitis and Suppress TH17 Immunity Potentially via Regulation of Galectin-4 and -9 Expression in the Gut

de Kivit, Sander, Morgan, Mary E., Koelink, Pim J., Zheng, Bin, Knippels, Léon, Verspaget, Hein W., Willemsen, Linette, Garssen, Johan, Kraneveld, Aletta D.

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

24

DCIR interacts with ligands from both endogenous and pathogenic origin

Bloem, Karien, Vuist, Ilona M., van den Berk, Meike, Klaver, Elsenoor J., van Die, Irma, Knippels, Léon M.J., Garssen, Johan, García-Vallejo, Juan J., van Vliet, Sandra J., van Kooyk, Yvette

Journal:

Immunology Letters

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

25

Assessment of Protein Allergenicity on the Basis of Immune Reactivity: Animal Models

Ian Kimber, Rebecca J. Dearman, Andre H. Penninks, Leon M. J. Knippels, Robert B. Buchanan, Bruce Hammerberg, Hilary A. Jackson and Ricki M. Helm

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 1.70 MB

english, 2003

26

P22 – Set-up and validation of a mouse model for food-allergy induced atopic dermatitis

Rijnierse, Anneke, Veening, Desiree, Wehkamp, Tjalling, Jeurink, Prescilla, Garssen, Johan, Knippels, Leon

Journal:

Clinical and Translational Allergy

Year:

2014

Language:

english

File:

PDF, 88 KB

english, 2014

27

Characterization of T Cell Epitopes in Bovine a-Lactalbumin

Meulenbroek, Laura A.P.M., den Hartog Jager, Constance F., Lebens, Ans F.M., Knulst, André C., Bruijnzeel-Koomen, Carla A.F.M., Garssen, Johan, Knippels, Léon M.J., van Hoffen, Els

Journal:

International Archives of Allergy and Immunology

Year:

2014

Language:

english

File:

PDF, 197 KB

english, 2014

28

Reversible Denaturation of Brazil Nut 2S Albumin (Ber e1) and Implication of Structural Destabilization on Digestion by Pepsin

Koppelman, Stef J., Nieuwenhuizen, Willem F., Gaspari, Marco, Knippels, Leon M. J., Penninks, André H., Knol, Edward F., Hefle, Susan L., de Jongh, Harmen H. J.

Journal:

Journal of Agricultural and Food Chemistry

Year:

2005

Language:

english

File:

PDF, 296 KB

english, 2005

29

Allergenicity assessment of hydrolyzed cow's milk based infant formula

Knippels, Leon, Garssen, Johan

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 67 KB

english, 2014

30

Immunotherapy - risk/benefit in food allergy

Kostadinova, Atanaska I., Willemsen, Linette E. M., Knippels, Léon M. J., Garssen, Johan

Journal:

Pediatric Allergy and Immunology

Year:

2013

Language:

english

File:

PDF, 433 KB

english, 2013

31

Assessment of Protein Allergenicity on the Basis of Immune Reactivity: Animal Models

Kimber, Ian, Dearman, Rebecca J., Penninks, Andre H., Knippels, Leon M.J., Buchanan, Robert B., Hammerberg, Bruce, Jackson, Hilary A., Helm, Ricki M.

Journal:

Environmental Health Perspectives

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

32

Invariant Natural Killer T Cells Contribute to the Allergic Response in Cows Milk Protein-Sensitized Mice

Schouten, Bastiaan, van Esch, Betty C.A.M., Lim, Stephanie M., Hofman, Gerard A., Knippels, Léon M.J., Willemsen, Linette E.M., Vos, Arjan P., Garssen, Johan

Journal:

International Archives of Allergy and Immunology

Year:

2012

Language:

english

File:

PDF, 884 KB

english, 2012

33

Enzymatic Treatment of Whey Proteins in Cows Milk Results in Differential Inhibition of IgE-Mediated Mast Cell Activation Compared to T-Cell Activation

Knipping, Karen, van Esch, Betty C.A.M., van Ieperen-van Dijk, Adrie G., van Hoffen, Els, van Baalen, Ton, Knippels, Léon M.J., van der Heide, Sicco, Dubois, Anthony E.J., Garssen, Johan, Knol, Edward

Journal:

International Archives of Allergy and Immunology

Year:

2012

Language:

english

File:

PDF, 537 KB

english, 2012

34

Role of Cellular Immunity in Cow’s Milk Allergy: Pathogenesis, Tolerance Induction, and Beyond

Jo, Juandy, Garssen, Johan, Knippels, Leon, Sandalova, Elena

Journal:

Mediators of Inflammation

Year:

2014

Language:

english

File:

PDF, 310 KB

english, 2014

35

Human Milk Blocks DC-SIGN–Pathogen Interaction via MUC1

Koning, Nathalie, Kessen, Sabine F. M., Van Der Voorn, J. Patrick, Appelmelk, Ben J., Jeurink, Prescilla V., Knippels, Leon M. J., Garssen, Johan, Van Kooyk, Yvette

Journal:

Frontiers in Immunology

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

36

The Consequences of Multiple Simultaneous C-Type Lectin–Ligand Interactions: DCIR Alters the Endo-Lysosomal Routing of DC-SIGN

García-Vallejo, Juan J., Bloem, Karien, Knippels, Léon M. J., Garssen, Johan, van Vliet, Sandra J., van Kooyk, Yvette

Journal:

Frontiers in Immunology

Year:

2015

Language:

english

File:

PDF, 2.95 MB

english, 2015

37

A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates

Schouten, Bastiaan, van Esch, Betty C. A. M., Hofman, Gerard A., de Kivit, Sander, Boon, Louis, Knippels, Léon M. J., Garssen, Johan, Willemsen, Linette E. M.

Journal:

British Journal Of Nutrition

Year:

2012

Language:

english

File:

PDF, 307 KB

english, 2012

38

Difficulties in Describing Allergic Disease Modulation by Pre-, Pro- and Synbiotics

V. Jeurink, Prescilla, Rijnierse, Anneke, Martin, Rocio, Garssen, Johan, M. J. Knippels, Leon

Journal:

Current Pharmaceutical Design

Year:

2012

Language:

english

File:

PDF, 114 KB

english, 2012

39

Protein Allergenicity: Rat Model

Knippels, Léon M. J., Penninks, André H.

Journal:

Comments on Toxicology

Year:

2002

Language:

english

File:

PDF, 229 KB

english, 2002

40

Animal models of anaphylaxis

Nauta, Alma, Knippels, Leon, Garssen, Johan, Redegeld, Frank

Journal:

Current Opinion in Allergy and Clinical Immunology

Year:

2007

Language:

english

File:

PDF, 99 KB

english, 2007

41

A specific mixture of short chain galacto-oligosaccharides and long chain fructo-oligosaccharides induces an anti-allergic immunoglobulin profile in infants at risk for allergy

Garssen, Johan, Arsnalognu, Sertac, Boehm, Gunther, Moro, Guido, Faber, Joyce, Knol, Edward, Ruiter, Bert, Hoffen, Els, Willemsen, Linette, M'Rabet, Laura, Knippels, Léon M.J.

Journal:

World Allergy Organization Journal

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

42

Serum biomarkers for allergy in children

Knipping, Karen, Knippels, Léon M.J., Dupont, Christophe, Garssen, Johan

Journal:

Pediatric Allergy and Immunology

Year:

2016

Language:

english

File:

PDF, 845 KB

english, 2016

43

Assessment of the Allergic Potential of Food Protein Extracts and Proteins on Oral Application Using the Brown Norway Rat Model

Léon M. J. Knippels and André H. Penninks

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 2.41 MB

english, 2003

44

A dietary intervention with non-digestible oligosaccharides and partial hydrolysed whey protein prevents the onset of food allergic symptoms in mice

van Esch, Betty C.A.M., Kostadinova, Atanaska I., Garssen, Johan, Willemsen, Linette E.M., Knippels, Léon M.J.

Journal:

PharmaNutrition

Year:

2017

Language:

english

File:

PDF, 947 KB

english, 2017

45

Assessment of the Allergic Potential of Food Protein Extracts and Proteins on Oral Application Using the Brown Norway Rat Model

Knippels, Léon M.J., Penninks, André H.

Journal:

Environmental Health Perspectives

Year:

2003

Language:

english

File:

PDF, 290 KB

english, 2003

46

Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation

de Kivit, Sander, Kostadinova, Atanaska I., Kerperien, JoAnn, Morgan, Mary E., Muruzabal, Veronica Ayechu, Hofman, Gerard A., Knippels, Leon M. J., Kraneveld, Aletta D., Garssen, Johan, Willemsen, Lin

Journal:

Journal of Leukocyte Biology

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

47

PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention

Kostadinova, Atanaska I., Middelburg, Jim, Ciulla, Michele, Garssen, Johan, Hennink, Wim E., Knippels, Leon M.J., van Nostrum, Cornelus F., Willemsen, Linette E.M.

Journal:

European Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 2.88 MB

english, 2017

48

Galectin-9 Produced by Intestinal Epithelial Cells Enhances Aldehyde Dehydrogenase Activity in Dendritic Cells in a PI3K- and p38-Dependent Manner

de Kivit, Sander, Kostadinova, Atanaska I., Kerperien, JoAnn, Ayechu Muruzabal, Veronica, Morgan, Mary E., Knippels, Leon M.J., Kraneveld, Aletta D., Garssen, Johan, Willemsen, Linette E.M.

Journal:

Journal of Innate Immunity

Year:

2017

Language:

english

File:

PDF, 449 KB

english, 2017

49

Intestinal Epithelium-Derived Galectin-9 Is Involved in the Immunomodulating Effects of Nondigestible Oligosaccharides

de Kivit, Sander, Kraneveld, Aletta D., Knippels, Leon M.J., van Kooyk, Yvette, Garssen, Johan, Willemsen, Linette E.M.

Journal:

Journal of Innate Immunity

Year:

2013

Language:

english

File:

PDF, 996 KB

english, 2013

50

Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides

Scholtens, Petra A. M. J., Alliet, Philippe, Raes, Marc, Alles, Martine S., Kroes, Hilde, Boehm, Guenther, Knippels, Leon M. J., Knol, Jan, Vandenplas, Yvan

Journal:

Journal of Nutrition

Year:

2008

Language:

english

File:

PDF, 709 KB

english, 2008

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